anti-YTHDC2 antibody

Product Name

YTHDC2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein binds to N6-methyladenosine, a common modified RNA nucleotide that is enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. Binding of proteins to this modified nucleotide may regulate mRNA translation and stability. This gene may be associated with susceptibility to pancreatic cancer in human patients, and knockdown of this gene resulted in reduced proliferation in a human liver cancer cell line.

IMMUNOGEN INFORMATION

Immunogen

3'-5' RNA helicase YTHDC2

Synonyms

YTHDC2, CAHL

Observed MW

160 kDa

APPLICATION

Tested Application

ELISA, WB, IF

Recommended Dilution

WB: 1:500-1:2000; IF: 1:50-1:200

UNIPROT INFORMATION

UniProt ID

Q9H6S0

IMAGES

Immunofluorescent analysis of NIH/3T3 cells using FNab10487(YTHDC2 antibody) at dilution of 1:50.

rat testis tissue were subjected to SDS PAGE followed by western blot with FNab10487(YTHDC2 antibody) at dilution of 1:1000