anti-TLR2 antibody

Product Name

TLR2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants.

IMMUNOGEN INFORMATION

Immunogen

Toll-like receptor 2

Synonyms

CD282, TIL4, TLR2

Observed MW

105 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:200

UNIPROT INFORMATION

UniProt ID

O60603

IMAGES

Immunohistochemistry of paraffin-embedded Rat spleen tissue slide using FNab10498(TLR2 antibody) at dilution of 1:50

Rat spleen tissue were subjected to SDS PAGE followed by western blot with FNab10498(TLR2 antibody) at dilution of 1:1000