anti- LILRB4 antibody

Product Name

LILRB4 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

IMMUNOGEN INFORMATION

Immunogen

Leukocyte immunoglobulin-like receptor subfamily B member 4

Synonyms

LILRB4, CD85K, ILT-3, ILT3, LIR-5, LIR5

Observed MW

49 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:200

UNIPROT INFORMATION

UniProt ID

Q8NHJ6

IMAGES

Immunohistochemistry of paraffin-embedded human colon cancer slide using FNab10516(LILRB4 antibody) at dilution of 1:50

A549 cells were subjected to SDS PAGE followed by western blot with FNab10516(LILRB4 antibody) at dilution of 1:1000