anti- Cytokeratin 1 antibody

Our Anti-Cytokeratin 1 Antibody, available in a 100µg size, is a versatile tool for researchers investigating cytokeratin 1, a key intermediate filament protein found in epithelial cells. Cytokeratin 1 is often used as a marker for epithelial differentiation and is important for understanding cell biology, tissue development, and cancer research.

This antibody has been rigorously validated for specificity and sensitivity, ensuring reliable results in your experiments, whether you're performing immunohistochemistry, immunofluorescence, or Western blotting. Its compact size provides the flexibility to explore cytokeratin 1 expression in various tissues and cell types.

By using our Anti-Cytokeratin 1 Antibody, you can gain deeper insights into the role of cytokeratin 1 in epithelial cell biology and its potential implications in disease processes. Trust in the quality of our antibody to advance your research and contribute to our understanding of cytokeratins in cellular function and pathology.

Product Name

Cytokeratin 1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Keratins are a large family of proteins that form the intermediate filament cytoskeleton of epithelial cells, which are classified into two major sequence types. Type I keratins are a group of acidic intermediate filament proteins, including K9–K23, and the hair keratins Ha1–Ha8. Type II keratins are the basic or neutral courterparts to the acidic type I keratins, including K1–K8, and the hair keratins Ha1–Ha8. Type II keratins are the basic or neutral courterparts to the acidic type I keratins, including K1–K8, and the hair keratins, Hb1–Hb6. Keratin-1 is type II keratin. It is a specific marker for terminal differentiation in mammalian epidermis. It is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. This antibody is specifically against ketatin I.

IMMUNOGEN INFORMATION

Immunogen

keratin 1

Synonyms

67 kDa cytokeratin, CK 1, CK1, Cytokeratin 1, keratin 1, KRT1

Observed MW

67 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:5000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

P04264

IMAGES

Immunohistochemistry of paraffin-embedded human esophagus tissue slide using FNab10707(Cytokeratin 1 antibody) at dilution of 1:100