anti- CADM1 antibody

Delve into the intricate functions of CADM1 with our Anti-CADM1 Antibody, now available in a 100µg vial. CADM1, also known as SynCAM1, is a cell adhesion molecule crucial for synaptic differentiation and neural development.

Our meticulously developed and rigorously tested Anti-CADM1 Antibody empowers you to explore the functions and roles of CADM1 with precision and accuracy. Whether you're investigating its roles in neuronal connectivity, synapse formation, or its implications in neurodevelopmental disorders, this antibody ensures reliable results.

This versatile antibody is optimized for various applications, including immunohistochemistry, Western blotting, and immunoprecipitation. With its robust performance, you can confidently investigate CADM1 in diverse experimental setups.

Each 100µg vial of this antibody offers value and flexibility, allowing you to advance scientific knowledge and contribute to our understanding of CADM1's significance in synaptic function and neurobiology with confidence.

Product Name

CADM1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer(NSCLC) cells. Interaction with CRTAM promotes natural killer(NK) cell cytotoxicity and interferon-gamma(IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly(By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.

IMMUNOGEN INFORMATION

Immunogen

cell adhesion molecule 1

Synonyms

IGSF4, IGSF4A,

Observed MW

49-67 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:50-1:200

UNIPROT INFORMATION

UniProt ID

Q9BY67

IMAGES

Immunohistochemistry of paraffin-embedded rat brain tissue slide using FNab10751(CADM1 antibody) at dilution of 1:100

A549 cell lysates were subjected to SDS PAGE followed by western blot with FNab10751(CADM1 antibody) at dilution of 1:1000