anti- DNMT1 antibody

Uncover the secrets of DNA methylation and epigenetic regulation with our Anti-DNMT1 Antibody, now available in a convenient 100µg size. DNMT1 (DNA (Cytosine-5-)-Methyltransferase 1) is a pivotal enzyme responsible for maintaining DNA methylation patterns during DNA replication.

This antibody is designed to offer exceptional specificity and sensitivity, ensuring the precise detection of DNMT1 protein in your experiments. Researchers exploring epigenetics, DNA methylation, or related fields will appreciate the accuracy and reliability that this antibody brings to their work.

Our high-quality Anti-DNMT1 Antibody undergoes rigorous quality control to guarantee consistent and reproducible results, allowing you to advance your research with confidence. Investigate the dynamic world of DNA methylation and the vital role DNMT1 plays in maintaining epigenetic information. Whether you are researching DNA methylation patterns in development, disease, or other contexts, our Anti-DNMT1 Antibody empowers you to make significant strides in understanding these fundamental processes.

Product Name

DNMT1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes(TSGs) or other tumor-related genes in colorectal cancer(CRC) cells(PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells(ESCs)(PubMed:24623306). Associates at promoter regions of tumor suppressor genes(TSGs) leading to their gene silencing(PubMed:24623306). Promotes tumor growth(PubMed:24623306).

IMMUNOGEN INFORMATION

Immunogen

DNA(cytosine-5-)-methyltransferase 1

Synonyms

AIM, CXXC9, DNA MTase HsaI, DNMT, DNMT1, MCMT

APPLICATION

Tested Application

ELISA, IHC

Recommended Dilution

IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

P26358

IMAGES

Immunohistochemistry of paraffin-embedded human stomach using FNab10776(DNMT1 antibody) at dilution of 1:100