anti- FURIN antibody

Dive into the fascinating realm of protease regulation and its impact on cellular processes with our Anti-FURIN Antibody, available in a 100µg vial. Furin is a critical protease involved in the cleavage and activation of various proproteins, influencing diverse biological mechanisms. This highly specific antibody empowers researchers to explore Furin's functions, contributing to a deeper understanding of protease regulation and its role in health and disease.

Key Features:

• Exceptional Specificity: Our Anti-FURIN Antibody is meticulously tested to specifically target Furin, minimizing the risk of cross-reactivity.
• Versatile Applications: Ideal for a wide range of experimental techniques, including Western blotting, immunohistochemistry, and studies related to protease activity.
• Sufficient Quantity: With 100µg, you have ample antibody for multiple experiments.
• High-Quality Standards: Manufactured to meet stringent industry standards, ensuring consistent and reproducible results.
• Advance Your Research: Whether you're focused on protease regulation, proprotein activation, or Furin's functions, our Anti-FURIN Antibody offers precision and versatility.

Product Name

FURIN antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants.

IMMUNOGEN INFORMATION

Immunogen

furin (paired basic amino acid cleaving enzyme)

Synonyms

FUR, PACE, PCSK3

APPLICATION

Tested Application

ELISA, IHC

Recommended Dilution

IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

P09958

IMAGES

Immunohistochemistry of paraffin-embedded human prostate slide using FNab10786( FURIN Antibody) at dilution of 1:100