UHRF1 Monoclonal Antibody

This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.

The UHRF1 Monoclonal Antibody, offered by Dana Biosciences, is a highly specific and sensitive tool for the detection and analysis of UHRF1 protein expression in various biological samples. This antibody has been rigorously tested and validated for use in a wide range of applications, including Western blotting, immunoprecipitation, and immunohistochemistry.

The UHRF1 Monoclonal Antibody is produced using advanced recombinant DNA technology and is of the highest quality, ensuring consistent and reliable results. It is supplied in a convenient format, with a concentration of 1 mg/mL, and is available in various sizes to suit different experimental needs.

This antibody is an essential tool for researchers studying epigenetic regulation, DNA methylation, and cell cycle control, as UHRF1 plays a critical role in these processes. Its high specificity and sensitivity make it an ideal choice for both basic research and clinical applications.

Overall, the UHRF1 Monoclonal Antibody from Dana Biosciences is a valuable addition to any researcher's toolkit, providing accurate and reproducible results for a wide range of applications.