STAT1 mouse Monoclonal Antibody(12E8)

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.

The STAT1 Mouse Monoclonal Antibody (12E8) is a highly specific and reliable tool for the detection and analysis of STAT1 protein expression in various biological samples. This antibody is produced using advanced monoclonal antibody technology, ensuring high affinity and specificity towards STAT1.

The STAT1 protein plays a crucial role in the regulation of cellular responses to various cytokines and growth factors. It is involved in the activation of numerous signaling pathways, including the JAK-STAT pathway, which is essential for immune responses, cell growth, and differentiation. The STAT1 Mouse Monoclonal Antibody (12E8) recognizes both the phosphorylated and non-phosphorylated forms of STAT1, enabling comprehensive analysis of its activation status.

This antibody has been extensively validated for various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent sensitivity and specificity, allowing for accurate and reliable detection of STAT1 protein in different experimental settings. Furthermore, it has been tested and validated in multiple species, including human, mouse, and rat, ensuring its broad applicability.

The STAT1 Mouse Monoclonal Antibody (12E8) is supplied as a purified and concentrated solution, ready for immediate use. It is provided in a convenient format, allowing for easy storage and handling. With its exceptional performance and versatility, this antibody is an indispensable tool for researchers studying the role of STAT1 in various biological processes and diseases.

Note: For research use only. Not for diagnostic or therapeutic purposes.