PTEN mouse Monoclonal Antibody(2C10)

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. 

The PTEN Mouse Monoclonal Antibody (2C10) is a highly specific and sensitive antibody designed for the detection and quantification of PTEN protein expression in various biological samples. This antibody is produced using advanced monoclonal antibody technology and is derived from mouse hybridoma cells. It has been extensively validated for use in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. The PTEN Mouse Monoclonal Antibody (2C10) exhibits high affinity and specificity towards PTEN protein, making it an ideal tool for researchers and scientists working in the fields of cancer biology, cell signaling, and molecular biology. This antibody is supplied in a convenient and easy-to-use format, and is available in various sizes to meet the specific needs of different research applications. With its exceptional performance and reliability, the PTEN Mouse Monoclonal Antibody (2C10) is an essential tool for any laboratory conducting research in the field of PTEN protein expression and function.