Phospho-Stat3 (Y705) mouse Monoclonal Antibody(1E9)

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. 

The PHOSPHO-STAT3 (Y705) Mouse Monoclonal Antibody (1E9) is a highly specific and reliable tool for the detection and analysis of phosphorylated STAT3 at tyrosine 705 residue. This antibody is produced using advanced monoclonal antibody technology, ensuring exceptional quality and consistency.

STAT3 is a crucial transcription factor involved in various cellular processes, including cell growth, differentiation, and survival. Phosphorylation of STAT3 at tyrosine 705 residue is a key event in its activation, leading to its nuclear translocation and subsequent regulation of target gene expression.

The PHOSPHO-STAT3 (Y705) Mouse Monoclonal Antibody (1E9) has been extensively validated for its specificity and sensitivity in various experimental applications, such as Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated STAT3 and other related proteins, ensuring accurate and reliable results.

This antibody is supplied as a purified and concentrated solution, allowing for easy and efficient use in various experimental settings. It is compatible with a wide range of sample types, including cell lysates, tissue extracts, and cultured cells.

With its exceptional specificity and sensitivity, the PHOSPHO-STAT3 (Y705) Mouse Monoclonal Antibody (1E9) is an indispensable tool for researchers studying the role of phosphorylated STAT3 in cellular signaling pathways, cancer biology, and other related fields. Its high-quality performance and consistent results make it an ideal choice for reliable and reproducible experiments.