phospho-MLKL (S358) mouse Monoclonal Antibody(6F8)

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.

The PHOSPHO-MLKL (S358) Mouse Monoclonal Antibody (6F8) is a highly specific and reliable tool designed for the detection and analysis of phosphorylated mixed lineage kinase domain-like protein (MLKL) at serine 358 residue. This antibody is produced using advanced monoclonal antibody technology, ensuring exceptional quality and performance.

The PHOSPHO-MLKL (S358) Mouse Monoclonal Antibody (6F8) exhibits a high affinity and specificity towards the phosphorylated form of MLKL at serine 358, making it an ideal choice for researchers studying necroptosis, a regulated form of cell death. By targeting this specific phosphorylation site, this antibody enables precise and accurate analysis of MLKL activation and its involvement in necroptotic signaling pathways.

This antibody has been extensively validated through various experimental techniques, including Western blotting, immunoprecipitation, and immunofluorescence. It demonstrates excellent sensitivity and specificity, allowing for reliable and reproducible results in a wide range of applications.

The PHOSPHO-MLKL (S358) Mouse Monoclonal Antibody (6F8) is supplied as a purified and concentrated solution, ensuring maximum performance and ease of use. It is suitable for both in vitro and in vivo studies, providing researchers with a versatile tool for investigating the role of MLKL phosphorylation in various biological processes.

In summary, the PHOSPHO-MLKL (S358) Mouse Monoclonal Antibody (6F8) is a highly specific and reliable antibody that enables precise detection and analysis of phosphorylated MLKL at serine 358. With its exceptional quality and performance, this antibody is an invaluable tool for researchers studying necroptosis and its underlying mechanisms.