phospho-MLKL (S358) mouse Monoclonal Antibody(6B4)

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.

The PHOSPHO-MLKL (S358) Mouse Monoclonal Antibody (6B4) is a highly specific and reliable tool designed for the detection and analysis of phosphorylated mixed lineage kinase domain-like protein (MLKL) at serine 358 residue. This antibody is produced using advanced monoclonal antibody technology, ensuring exceptional quality and performance.

The PHOSPHO-MLKL (S358) Mouse Monoclonal Antibody (6B4) exhibits a high affinity and specificity towards the phosphorylated form of MLKL at serine 358, making it an ideal choice for researchers studying necroptosis, a regulated form of cell death. By targeting this specific phosphorylation site, this antibody enables precise and accurate analysis of MLKL activation and its involvement in necroptotic signaling pathways.

This antibody has been extensively validated for various applications, including Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry. Its exceptional sensitivity and specificity ensure reliable and reproducible results, allowing researchers to confidently investigate the role of MLKL in necroptosis and related cellular processes.

The PHOSPHO-MLKL (S358) Mouse Monoclonal Antibody (6B4) is supplied as a purified and concentrated solution, ready for immediate use. It is recommended to store this antibody at -20°C for long-term storage, ensuring its stability and functionality.

In summary, the PHOSPHO-MLKL (S358) Mouse Monoclonal Antibody (6B4) is a highly specific and reliable tool for the detection and analysis of phosphorylated MLKL at serine 358 residue. With its exceptional quality and performance, this antibody is an invaluable asset for researchers investigating necroptosis and related cellular processes.