Phospho-Akt (S473) mouse Monoclonal Antibody(6F8)

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.

The PHOSPHO-AKT (S473) Mouse Monoclonal Antibody (6F8) is a highly specific and reliable tool for the detection and analysis of phosphorylated AKT at serine 473 residue. This antibody is produced using advanced monoclonal antibody technology, ensuring exceptional quality and consistency.

The PHOSPHO-AKT (S473) Mouse Monoclonal Antibody (6F8) exhibits excellent sensitivity and specificity, making it an ideal choice for various applications, including western blotting, immunohistochemistry, and immunofluorescence. It recognizes the phosphorylated form of AKT at serine 473 residue with high affinity, enabling accurate and precise quantification of AKT activation levels.

This antibody is meticulously validated and extensively tested to ensure optimal performance and reproducibility. It has been rigorously evaluated for its specificity, sensitivity, and cross-reactivity to ensure reliable and accurate results. The PHOSPHO-AKT (S473) Mouse Monoclonal Antibody (6F8) is manufactured under strict quality control standards, guaranteeing consistent and reliable performance batch after batch.

With its exceptional performance and reliability, the PHOSPHO-AKT (S473) Mouse Monoclonal Antibody (6F8) is an indispensable tool for researchers and scientists studying AKT signaling pathways and its role in various cellular processes. Its high specificity and sensitivity make it an invaluable asset in elucidating the intricate mechanisms of AKT activation and its implications in disease progression.

Choose the PHOSPHO-AKT (S473) Mouse Monoclonal Antibody (6F8) for accurate and reliable detection and analysis of phosphorylated AKT at serine 473 residue, and unlock new insights into AKT signaling pathways and its involvement in various biological processes.