MLKL mouse Monoclonal Antibody(8H7)

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.

The MLKL Mouse Monoclonal Antibody (8H7) is a highly specific and reliable tool for the detection and analysis of mixed lineage kinase domain-like protein (MLKL). This antibody is produced using advanced monoclonal antibody technology, ensuring high affinity and specificity for MLKL.

The MLKL Mouse Monoclonal Antibody (8H7) has been extensively validated for various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional sensitivity and minimal cross-reactivity, enabling accurate and precise detection of MLKL in various biological samples.

With its superior performance characteristics, the MLKL Mouse Monoclonal Antibody (8H7) is an invaluable asset for researchers studying necroptosis, a regulated form of cell death mediated by MLKL. It enables the investigation of MLKL expression, localization, and activation, providing crucial insights into the molecular mechanisms underlying necroptosis.

The MLKL Mouse Monoclonal Antibody (8H7) is supplied as a ready-to-use solution, ensuring convenience and ease of use. It is compatible with a wide range of experimental protocols and can be used in both basic research and clinical applications.

Choose the MLKL Mouse Monoclonal Antibody (8H7) for its exceptional quality, reliability, and versatility. Accelerate your research and gain a deeper understanding of necroptosis with this highly specific and sensitive antibody.