Collagen IV mouse Monoclonal Antibody(8E5)

This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants.

The COLLAGEN IV Mouse Monoclonal Antibody (8E5) is a highly specific and reliable tool for the detection and analysis of Collagen IV in various biological samples. This antibody is produced using advanced monoclonal antibody technology, ensuring high affinity and specificity towards Collagen IV.

Collagen IV is a major component of the basement membrane, playing a crucial role in maintaining tissue integrity and providing structural support. The COLLAGEN IV Mouse Monoclonal Antibody (8E5) recognizes the alpha chains of Collagen IV, allowing for precise and accurate detection of this protein in immunohistochemistry, western blotting, and other applications.

With its exceptional sensitivity and low background, this antibody enables researchers to obtain reliable and reproducible results. It has been extensively validated in various experimental settings, demonstrating its robust performance and consistent performance.

The COLLAGEN IV Mouse Monoclonal Antibody (8E5) is supplied in a convenient and ready-to-use format, ensuring ease of use and saving valuable time in the laboratory. It is suitable for use in both research and diagnostic applications, making it an essential tool for scientists and clinicians studying Collagen IV-related diseases and disorders.

In summary, the COLLAGEN IV Mouse Monoclonal Antibody (8E5) is a highly specific and reliable antibody that enables accurate detection and analysis of Collagen IV. Its exceptional sensitivity, low background, and convenient format make it an indispensable tool for researchers and clinicians in various fields of study.