CaMKII Beta/Gamma/Delta (Phospho Thr287) Monoclonal Antibody(4H2)

The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants.

The CAMKII Beta/Gamma/Delta (Phospho Thr287) Monoclonal Antibody (4H2) is a highly specific and reliable tool for the detection and analysis of CAMKII Beta, Gamma, and Delta isoforms phosphorylated at Thr287. This monoclonal antibody, designated as 4H2, has been meticulously developed and rigorously validated to ensure its exceptional performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence.

CAMKII (Calcium/Calmodulin-Dependent Protein Kinase II) is a crucial enzyme involved in numerous cellular processes, including synaptic plasticity, learning, and memory. The phosphorylation of CAMKII at Thr287 is a critical event that regulates its activity and function. The CAMKII Beta, Gamma, and Delta isoforms play distinct roles in different tissues and cellular contexts, making their precise detection and analysis essential for understanding their physiological and pathological implications.

The CAMKII Beta/Gamma/Delta (Phospho Thr287) Monoclonal Antibody (4H2) exhibits exceptional specificity and sensitivity, enabling accurate detection of the phosphorylated forms of CAMKII Beta, Gamma, and Delta. This antibody has been extensively characterized using various experimental approaches, ensuring its reliability and reproducibility. It has been validated for use in multiple applications, including Western blotting, where it demonstrates a strong signal with minimal background noise. Additionally, it can be employed in immunoprecipitation experiments to isolate and study CAMKII Beta, Gamma, and Delta isoforms phosphorylated at Thr287. Furthermore, its compatibility with immunofluorescence techniques allows for the visualization and localization of these phosphorylated isoforms within cells and tissues.

The CAMKII Beta/Gamma/Delta (Phospho Thr287) Monoclonal Antibody (4H2) is manufactured under stringent quality control measures to ensure batch-to-batch consistency and reliability. It is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation steps. The antibody is provided in a convenient format, allowing for easy storage and handling.

In summary, the CAMKII Beta/Gamma/Delta (Phospho Thr287) Monoclonal Antibody (4H2) is a highly specific and reliable tool for the detection and analysis of CAMKII Beta, Gamma, and Delta isoforms phosphorylated at Thr287. Its exceptional performance in various applications, combined