AKT mouse Monoclonal Antibody(1E11)

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.

The AKT Mouse Monoclonal Antibody (1E11) is a highly specific and reliable tool for the detection and analysis of AKT protein expression in various biological samples. This monoclonal antibody has been meticulously developed and rigorously tested to ensure its exceptional quality and performance.

The AKT Mouse Monoclonal Antibody (1E11) exhibits a high affinity and selectivity towards AKT, a crucial protein involved in multiple cellular processes such as cell survival, proliferation, and metabolism. Its exceptional specificity allows for accurate and precise detection of AKT protein levels, enabling researchers to gain valuable insights into the intricate signaling pathways regulated by AKT.

This antibody has been extensively validated for various applications, including Western blotting, immunohistochemistry, and immunofluorescence. Its robust performance across these techniques ensures reliable and reproducible results, making it an indispensable tool for researchers in the field of molecular biology and cellular signaling.

The AKT Mouse Monoclonal Antibody (1E11) is manufactured using state-of-the-art techniques and undergoes stringent quality control measures to guarantee its consistency and reliability. It is produced in a sterile and controlled environment, ensuring the absence of contaminants that could compromise experimental outcomes.

With its exceptional specificity, reliability, and versatility, the AKT Mouse Monoclonal Antibody (1E11) is an invaluable asset for researchers seeking to unravel the intricate mechanisms underlying AKT signaling. Its superior performance and consistent results make it an indispensable tool for advancing scientific knowledge and driving breakthrough discoveries in the field of cellular biology.