eIF4A1 Monoclonal Antibody(M8)

function:ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.,similarity:Belongs to the DEAD box helicase family.,similarity:Belongs to the DEAD box helicase family. eIF4A subfamily.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,subunit:eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with PAIP1, EIF4E and RENT2. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. May interact with NOM1.,

The EIF4A1 Monoclonal Antibody (M8) is a highly specific and sensitive antibody designed for the detection and quantification of EIF4A1 protein in various biological samples. This antibody is produced using advanced monoclonal antibody technology and has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunoprecipitation, and immunohistochemistry.

The EIF4A1 protein is a key component of the eukaryotic translation initiation complex and plays a critical role in the regulation of protein synthesis. Dysregulation of EIF4A1 has been implicated in various diseases, including cancer, making it an important target for research and therapeutic development.

The M8 monoclonal antibody is highly specific to EIF4A1 and does not cross-react with other related proteins, ensuring accurate and reliable results. It has been extensively validated in various cell lines and tissues, making it a valuable tool for researchers studying EIF4A1 function and regulation.

In summary, the EIF4A1 Monoclonal Antibody (M8) is a highly specific and sensitive antibody that is ideal for the detection and quantification of EIF4A1 protein in various biological samples. Its high specificity and sensitivity make it a valuable tool for researchers studying EIF4A1 function and regulation in various diseases, including cancer.