VE-Cadherin(Phospho Tyr731) Polyclonal Antibody

This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer.

The VE-Cadherin (Phospho Tyr731) Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of VE-Cadherin protein phosphorylated at tyrosine 731. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and sensitivity.

VE-Cadherin, also known as Cadherin-5 or CDH5, is a transmembrane glycoprotein that plays a crucial role in cell-cell adhesion and vascular integrity. Phosphorylation of VE-Cadherin at tyrosine 731 has been implicated in various cellular processes, including endothelial cell migration, angiogenesis, and vascular permeability.

This polyclonal antibody is rigorously validated for its specificity and performance in various applications, such as Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated VE-Cadherin and other related proteins, ensuring accurate and reliable results.

The VE-Cadherin (Phospho Tyr731) Polyclonal Antibody is supplied as a liquid formulation, ready to use for immediate experimentation. It is provided in a convenient size, allowing for multiple experiments without compromising the quality and performance.

Researchers and scientists in the fields of cell biology, vascular biology, and angiogenesis will greatly benefit from the use of this antibody in their studies. Its high specificity and sensitivity make it an indispensable tool for investigating the role of VE-Cadherin phosphorylation in various physiological and pathological processes.

In summary, the VE-Cadherin (Phospho Tyr731) Polyclonal Antibody is a reliable and specific reagent that enables accurate detection and analysis of phosphorylated VE-Cadherin. Its high performance and versatility make it an essential tool for researchers aiming to unravel the intricate mechanisms underlying cell adhesion and vascular integrity.