Vav1(Phospho Tyr174) Polyclonal Antibody

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

The VAV1(PHOSPHO TYR174) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of VAV1 protein phosphorylated at tyrosine 174 residue. This antibody is produced using advanced polyclonal antibody production techniques, ensuring high affinity and specificity towards the target protein.

The VAV1(PHOSPHO TYR174) Polyclonal Antibody is suitable for various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It enables researchers to investigate the phosphorylation status of VAV1 protein in different cellular contexts, providing valuable insights into its functional role in signal transduction pathways.

This antibody exhibits exceptional performance in terms of sensitivity and specificity, allowing for accurate and reliable detection of VAV1 protein phosphorylated at tyrosine 174 residue. It has been extensively validated in various experimental settings, ensuring consistent and reproducible results.

The VAV1(PHOSPHO TYR174) Polyclonal Antibody is supplied in a convenient and ready-to-use format, eliminating the need for time-consuming antibody purification steps. It is provided in a liquid formulation, ensuring ease of use and minimizing the risk of sample contamination.

With its exceptional quality and performance, the VAV1(PHOSPHO TYR174) Polyclonal Antibody is an indispensable tool for researchers studying VAV1 protein phosphorylation and its implications in cellular signaling pathways.