UNC5C Polyclonal Antibody

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region.

The UNC5C Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of UNC5C protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human UNC5C protein. The resulting polyclonal antibody exhibits high affinity and specificity towards UNC5C protein, making it an ideal tool for various applications in research and diagnostics.

The UNC5C Polyclonal Antibody has been extensively validated for its performance in Western blotting, immunohistochemistry, and immunofluorescence assays. It recognizes a single band of approximately 100 kDa in Western blot analysis of human brain lysates, which corresponds to the expected molecular weight of UNC5C protein. In addition, this antibody has been shown to exhibit strong staining of UNC5C protein in formalin-fixed, paraffin-embedded human brain tissue sections, indicating its suitability for use in immunohistochemistry applications.

This antibody is supplied as a purified IgG fraction, which has been affinity-purified from rabbit serum using protein A chromatography. It is provided in a liquid format, which is ready-to-use for various applications. The UNC5C Polyclonal Antibody is a valuable tool for researchers and clinicians studying the role of UNC5C protein in various physiological and pathological processes.