TRPM8 Polyclonal Antibody

Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.,miscellaneous:Its expression in most prostate tumors as well as the presence of an immunogenic epitope suggest that it may be suitable for the design of peptide vaccination strategies for prostate cancers.,miscellaneous:The sensation of coolness triggered by eucalyptol or menthol may be explained by the fact that menthol and cool temperatures sensations are detected by this protein.,Belongs to the transient receptor family. LTrpC subfamily.,tissue specificity:Expressed in prostate. Also expressed in most in prostate tumors. Also expressed in non-prostatic primary tumors such as colon, lung, breast and skin tumors.,

The TRPM8 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of the Transient Receptor Potential Melastatin 8 (TRPM8) protein. This antibody is produced through a rigorous process, ensuring its high affinity and sensitivity towards TRPM8.

The TRPM8 protein is a member of the TRP superfamily of ion channels and is primarily expressed in sensory neurons. It plays a crucial role in the perception of cold temperatures and is involved in various physiological processes, including thermoregulation, pain sensation, and prostate cancer progression.

Our TRPM8 Polyclonal Antibody has been extensively validated for its specificity and functionality in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other TRP channels, ensuring accurate and reliable results.

With its exceptional performance and reliability, the TRPM8 Polyclonal Antibody is an indispensable tool for researchers and scientists studying the TRPM8 protein and its associated functions. Its high specificity and sensitivity make it an ideal choice for investigating the role of TRPM8 in various physiological and pathological conditions.

Order your TRPM8 Polyclonal Antibody today and unlock new insights into the intricate mechanisms governed by the TRPM8 protein.