Troponin I-C(Phospho Ser43) Polyclonal Antibody

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

The Troponin I-C (Phospho Ser43) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of Troponin I-C protein phosphorylated at Serine 43. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

Troponin I-C is a crucial component of the troponin complex, which plays a vital role in regulating muscle contraction. Phosphorylation of Troponin I-C at Serine 43 has been implicated in various physiological and pathological processes, making it an important biomarker for studying cardiac diseases and skeletal muscle disorders.

The Troponin I-C (Phospho Ser43) Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been rigorously validated to provide reliable and reproducible results, ensuring accurate detection and quantification of phosphorylated Troponin I-C.

This antibody is manufactured using state-of-the-art techniques and undergoes stringent quality control measures to ensure batch-to-batch consistency and optimal performance. It is supplied as a liquid formulation, ready for immediate use, eliminating the need for time-consuming reconstitution.

With its exceptional specificity, sensitivity, and reliability, the Troponin I-C (Phospho Ser43) Polyclonal Antibody is an indispensable tool for researchers and clinicians involved in cardiovascular and muscle-related studies. Its application in both basic research and clinical diagnostics makes it an invaluable asset in advancing our understanding and management of cardiac and skeletal muscle disorders.