TOPB1 Polyclonal Antibody

This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.

The TOPB1 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of TOPB1 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to a region of the human TOPB1 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards the target protein, making it an ideal tool for a wide range of applications in research and diagnostics.

The TOPB1 Polyclonal Antibody is validated for use in Western blotting, immunohistochemistry, and immunofluorescence assays. It has been shown to detect endogenous levels of TOPB1 protein in human, mouse, and rat tissues, as well as in cultured cells. The antibody is supplied as a purified IgG fraction, which has been affinity-purified from rabbit serum using protein A chromatography. This ensures high purity and minimal background staining in immunological assays.

The TOPB1 Polyclonal Antibody is a valuable tool for researchers studying DNA topoisomerases and their role in DNA replication, transcription, and repair. It can also be used in clinical settings to detect TOPB1 protein expression in cancer tissues, which may have prognostic and therapeutic implications. Overall, the TOPB1 Polyclonal Antibody is a reliable and versatile reagent that can enhance the accuracy and sensitivity of various immunological assays.