TNKS1 Polyclonal Antibody

Catalytic activity:NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.,May regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Has PARP activity and can modify TERF1, and thereby contribute to the regulation of telomere length.,PTM:ADP-ribosylated (-auto).,PTM:Phosphorylated on serine residues by MAPK kinases upon insulin stimulation.,Contains 1 PARP catalytic domain.,Contains 1 SAM (sterile alpha motif) domain.,Contains 15 ANK repeats.,subcellular location:Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1.,subunit:Oligomerizes and associates with TNKS2. Interacts with the cytoplasmic domain of LNPEP/Otase in SLC2A4/GLUT4-vesicles. Binds to the N-terminus of telomeric TERF1 via the ANK repeats. Found in a complex with POT1; TERF1 and TINF2.,tissue specificity:Ubiquitous; highest levels in testis.,

The TNKS1 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of TNKS1 protein expression in various biological samples. This antibody is produced through a rigorous process, ensuring its high affinity and specificity towards TNKS1. With its exceptional sensitivity, this antibody enables accurate and precise quantification of TNKS1 levels in both research and clinical settings.

The TNKS1 Polyclonal Antibody exhibits excellent performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. Its versatility allows for the investigation of TNKS1 expression patterns and localization in different tissues and cell types. Moreover, this antibody has been validated for use in multiple species, making it suitable for diverse experimental models.

This product is supplied in a convenient and ready-to-use format, ensuring ease of use and saving valuable time in the laboratory. Its high-quality formulation guarantees consistent and reproducible results, enabling researchers to obtain reliable data with every experiment. The TNKS1 Polyclonal Antibody is an essential tool for studying TNKS1 biology and its involvement in various cellular processes, including DNA repair, telomere maintenance, and Wnt signaling.

In summary, the TNKS1 Polyclonal Antibody is a superior reagent that offers exceptional sensitivity, specificity, and versatility for the detection and analysis of TNKS1 protein expression. Its reliable performance and ease of use make it an indispensable tool for researchers and clinicians alike, facilitating advancements in the understanding and treatment of TNKS1-related diseases.