TERT(Phospho Ser227) Polyclonal Antibody

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative sp

The TERT(PHOSPHO SER227) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of the phosphorylated serine 227 residue on the telomerase reverse transcriptase (TERT) protein. This antibody is produced using a polyclonal approach, ensuring a diverse range of antibodies that recognize the phosphorylated serine 227 residue with high affinity and specificity.

The TERT(PHOSPHO SER227) Polyclonal Antibody is meticulously validated for its performance in various applications, including Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry. It exhibits exceptional sensitivity and selectivity, enabling accurate and reliable detection of the phosphorylated serine 227 residue on TERT protein in various biological samples.

This antibody is manufactured using state-of-the-art techniques and undergoes rigorous quality control measures to ensure consistent and reproducible results. It is supplied as a liquid formulation, ready for immediate use, and is compatible with a wide range of experimental conditions and protocols.

The TERT(PHOSPHO SER227) Polyclonal Antibody is an indispensable tool for researchers studying telomerase biology, cellular senescence, and cancer research. Its high specificity and sensitivity make it an ideal choice for investigating the functional significance of the phosphorylation of serine 227 on TERT protein and its role in cellular processes.

Order the TERT(PHOSPHO SER227) Polyclonal Antibody today and unlock new insights into the intricate mechanisms underlying telomerase regulation and its implications in various diseases and biological processes.