Stat5a/b(Phospho Ser726/731) Polyclonal Antibody

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been

The STAT5A/B(PHOSPHO SER726/731) Polyclonal Antibody is a highly specific and reliable tool designed for the detection and quantification of phosphorylated STAT5A and STAT5B at serine residues 726 and 731. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

The phosphorylation of STAT5A and STAT5B at serine residues 726 and 731 plays a crucial role in the activation and regulation of these transcription factors. By targeting these phosphorylation sites, this antibody enables researchers to investigate the activation status of STAT5A and STAT5B in various cellular processes, including cell signaling, proliferation, and differentiation.

This polyclonal antibody exhibits exceptional sensitivity and selectivity, allowing for accurate and precise detection of phosphorylated STAT5A and STAT5B in a wide range of sample types, including cell lysates, tissue extracts, and biological fluids. Its robust performance ensures reliable and reproducible results, making it an ideal choice for both qualitative and quantitative analysis.

The STAT5A/B(PHOSPHO SER726/731) Polyclonal Antibody is validated for multiple applications, including Western blotting, immunohistochemistry, and immunofluorescence. Its versatility enables researchers to explore the phosphorylation status of STAT5A and STAT5B in different experimental setups and model systems.

With its exceptional quality and performance, this antibody is an indispensable tool for researchers studying the intricate mechanisms of STAT5A and STAT5B signaling pathways. Its reliable and accurate results contribute to a deeper understanding of cellular processes and facilitate the development of novel therapeutic strategies targeting these transcription factors.

Order the STAT5A/B(PHOSPHO SER726/731) Polyclonal Antibody today and unlock new insights into the phosphorylation dynamics of STAT5A and STAT5B, advancing your research in the field of cell biology and signaling pathways.