Stat2 Polyclonal Antibody

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.

The Stat2 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Stat2 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human Stat2 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards Stat2 protein, making it an ideal tool for various applications such as Western blotting, immunohistochemistry, and immunofluorescence.

The Stat2 Polyclonal Antibody is validated for use in human, mouse, and rat samples, and has been extensively tested to ensure consistent and reliable results. This antibody is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative. It is recommended to store the antibody at -20°C for long-term storage and to avoid repeated freeze-thaw cycles.

Overall, the Stat2 Polyclonal Antibody is a valuable tool for researchers studying the role of Stat2 protein in various biological processes, including immune response, cell growth, and differentiation. Its high specificity and sensitivity make it an ideal choice for detecting Stat2 protein in complex biological samples.