SMAD7 Polyclonal Antibody

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.

The SMAD7 polyclonal antibody is a highly specific and sensitive tool for the detection and quantification of SMAD7 protein expression in various biological samples. This antibody is produced using a unique polyclonal approach, which ensures high affinity and specificity towards the target protein. The SMAD7 polyclonal antibody is suitable for use in a wide range of applications, including western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated for its performance and reliability, making it an ideal choice for researchers and scientists working in the field of molecular biology and related disciplines. With its superior quality and performance, the SMAD7 polyclonal antibody is an essential tool for studying the role of SMAD7 in various cellular processes and disease states.