Smad2(Phospho Thr220) Polyclonal Antibody

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation

The SMAD2(PHOSPHO THR220) Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of SMAD2 protein phosphorylated at threonine 220. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and sensitivity for the target protein.

SMAD2 is a critical component of the transforming growth factor-beta (TGF-β) signaling pathway, playing a crucial role in various cellular processes such as cell proliferation, differentiation, and apoptosis. Phosphorylation of SMAD2 at threonine 220 is known to regulate its activity and downstream signaling events.

The SMAD2(PHOSPHO THR220) Polyclonal Antibody has been extensively validated for its specificity and performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated SMAD2 and other related proteins, ensuring accurate and reliable results.

With its high sensitivity and specificity, this antibody is an indispensable tool for researchers studying the TGF-β signaling pathway and its implications in various physiological and pathological conditions. Its superior performance and consistent results make it an ideal choice for both basic research and clinical applications.

The SMAD2(PHOSPHO THR220) Polyclonal Antibody is supplied in a convenient and ready-to-use format, allowing for easy and efficient experimentation. It is available in various sizes to accommodate different experimental needs.

In summary, the SMAD2(PHOSPHO THR220) Polyclonal Antibody is a highly reliable and specific tool for the detection and analysis of phosphorylated SMAD2 protein. Its advanced technology, superior performance, and broad range of applications make it an essential asset for researchers in the field of TGF-β signaling and related studies.