Smad2(Phospho Ser467) Polyclonal Antibody

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation

The SMAD2(PHOSPHO SER467) Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of SMAD2 protein phosphorylated at serine 467. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

SMAD2 is a crucial component of the transforming growth factor-beta (TGF-β) signaling pathway, playing a pivotal role in various cellular processes such as cell proliferation, differentiation, and apoptosis. Phosphorylation of SMAD2 at serine 467 is known to regulate its activity and downstream signaling events.

The SMAD2(PHOSPHO SER467) Polyclonal Antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate and reproducible results.

This antibody is supplied as a liquid formulation, allowing for easy handling and convenient storage. It is provided in a ready-to-use format, eliminating the need for time-consuming preparation steps. The SMAD2(PHOSPHO SER467) Polyclonal Antibody is compatible with a wide range of sample types, including cell lysates, tissue extracts, and cultured cells.

With its exceptional quality and reliability, the SMAD2(PHOSPHO SER467) Polyclonal Antibody is an indispensable tool for researchers and scientists studying the TGF-β signaling pathway and its associated cellular processes.