Smad1(Phospho Ser187) Polyclonal Antibody

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-med

The SMAD1(PHOSPHO SER187) Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of SMAD1 protein phosphorylated at serine 187. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

SMAD1 is a crucial member of the SMAD family, which plays a pivotal role in the transforming growth factor-beta (TGF-β) signaling pathway. Phosphorylation of SMAD1 at serine 187 is known to regulate its activity and function, making it an important site for investigation in various cellular processes.

The SMAD1(PHOSPHO SER187) Polyclonal Antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate detection and quantification of phosphorylated SMAD1 in diverse biological samples.

This antibody is manufactured using state-of-the-art techniques and undergoes rigorous quality control measures to ensure batch-to-batch consistency and reproducibility. It is supplied as a liquid formulation, ready for immediate use, and is compatible with a wide range of experimental conditions.

Researchers and scientists can rely on the SMAD1(PHOSPHO SER187) Polyclonal Antibody to facilitate their investigations into the intricate mechanisms of TGF-β signaling and its implications in various physiological and pathological processes. Its exceptional performance and reliability make it an indispensable tool for elucidating the role of phosphorylated SMAD1 in cellular signaling pathways.