SLAP1 Polyclonal Antibody

The C-terminal domain is essential for the homodimerization and the interaction with CBL. While the interaction with CBL is apparently mediated via the hydrophobic region of this domain, the highly charged region is apparently required for the homodimerization.,Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.,induction:By all-trans retinoic acid (ATRA). Induction is indirect and is mediated through other proteins.,PTM:Phosphorylated.,Contains 1 SH2 domain.,Contains 1 SH3 domain.,subcellular location:Colocalizes with endosomes.,subunit:Interacts with EPHA2, VAV1, LCP2 and PDGFRB (By similarity). Homodimer. Homodimerization and interaction with phosphorylated CBL occurs via its C-terminal domain. Interacts with phosphorylated proteins ZAP70, CD3Z, SYK and LAT via its SH2 domain.,tissue specificity:Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas.,

The SLAP1 polyclonal antibody is a highly specific and reliable tool for the detection and analysis of SLAP1 protein expression. This antibody has been meticulously developed and rigorously validated to ensure optimal performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

With its exceptional affinity and sensitivity, the SLAP1 polyclonal antibody enables accurate and precise quantification of SLAP1 protein levels in a wide range of biological samples. Its superior specificity ensures minimal cross-reactivity with other proteins, guaranteeing reliable and reproducible results.

The SLAP1 polyclonal antibody is manufactured using state-of-the-art techniques and undergoes stringent quality control measures to ensure batch-to-batch consistency and maximum performance. It is produced from high-quality immunogens, resulting in a highly purified antibody with minimal background noise.

This antibody is supplied in a convenient and user-friendly format, allowing for easy handling and storage. It is provided in a liquid form, ready-to-use for immediate application. The SLAP1 polyclonal antibody is compatible with various experimental conditions and can be used in both research and clinical settings.

Choose the SLAP1 polyclonal antibody for its exceptional specificity, sensitivity, and reliability. It is an indispensable tool for researchers and scientists seeking to unravel the intricate mechanisms involving SLAP1 protein and its role in various biological processes.