SIK1 Polyclonal Antibody

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-182 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,Transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. Potential role in G2/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.,Contains 1 protein kinase domain.,Contains 1 UBA domain.,subcellular location:Translocates to the cytoplasm on phosphorylation where it binds binding to YWHAZ.,subunit:Binds to and is activated by YWHAZ when phosphorylated on Thr-182.,

The SIK1 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of SIK1 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human SIK1 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards SIK1 protein, making it an ideal tool for various applications such as Western blotting, immunohistochemistry, and immunofluorescence.

The SIK1 Polyclonal Antibody is validated for use in human, mouse, and rat samples, and has been extensively tested for its specificity and sensitivity. It recognizes a single band of the expected molecular weight in Western blot analysis, and shows minimal cross-reactivity with other proteins. The antibody is supplied as a purified IgG fraction, and is suitable for use in both research and diagnostic applications.

In summary, the SIK1 Polyclonal Antibody is a reliable and high-quality reagent that enables accurate detection and quantification of SIK1 protein in various biological samples. Its high specificity and sensitivity make it an essential tool for researchers and clinicians working in the fields of cell biology, neuroscience, and cancer research.