Shc(Phospho Tyr427) Polyclonal Antibody

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.

The SHC(PHOSPHO TYR427) Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of the phosphorylated tyrosine residue at position 427 of the SHC protein. This antibody is produced using a polyclonal approach, ensuring a diverse range of antibodies that recognize the target with high affinity and specificity.

The SHC protein plays a crucial role in various cellular processes, including signal transduction and cell proliferation. The phosphorylation of tyrosine residue 427 is known to regulate the activation and downstream signaling of SHC, making it an important target for research in the field of cell biology and molecular signaling pathways.

This polyclonal antibody has been extensively validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate and reproducible results in both qualitative and quantitative analyses.

The SHC(PHOSPHO TYR427) Polyclonal Antibody is manufactured using state-of-the-art techniques and undergoes rigorous quality control measures to ensure batch-to-batch consistency and reliability. It is supplied as a liquid formulation, ready for immediate use, and is compatible with a wide range of experimental conditions and sample types.

Researchers and scientists can confidently rely on the SHC(PHOSPHO TYR427) Polyclonal Antibody to facilitate their investigations into the intricate mechanisms of cellular signaling pathways and gain valuable insights into the role of SHC in various physiological and pathological processes.