Shc(Phospho Tyr349) Polyclonal Antibody

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.

The SHC(PHOSPHO TYR349) Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of phosphorylated tyrosine 349 on the SHC protein. This antibody is produced using advanced polyclonal antibody production techniques, ensuring high affinity and specificity towards the target epitope.

The SHC protein plays a crucial role in various cellular processes, including signal transduction and cell proliferation. Phosphorylation of tyrosine 349 on the SHC protein has been implicated in the regulation of downstream signaling pathways, making it an important target for research in the field of cell biology and molecular signaling.

This polyclonal antibody is rigorously validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate and reproducible results in experimental studies.

The SHC(PHOSPHO TYR349) Polyclonal Antibody is manufactured using high-quality materials and state-of-the-art production processes, ensuring batch-to-batch consistency and reliability. It is supplied as a liquid formulation, ready for immediate use without the need for additional reagents or preparations.

Researchers and scientists can confidently rely on the SHC(PHOSPHO TYR349) Polyclonal Antibody to facilitate their investigations into the intricate mechanisms of cellular signaling pathways. Its exceptional performance and specificity make it an indispensable tool for elucidating the role of phosphorylated tyrosine 349 on the SHC protein in various physiological and pathological conditions.

Note: This product is for research use only and is not intended for diagnostic or therapeutic purposes.