SEM6D Polyclonal Antibody

Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner.

The SEM6D polyclonal antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of SEM6D protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to a unique epitope of the SEM6D protein. The resulting polyclonal antibody exhibits high affinity and specificity towards the target protein, making it an ideal tool for a wide range of applications in research and diagnostics.

The SEM6D polyclonal antibody has been extensively validated for its performance in various immunoassays, including Western blotting, immunohistochemistry, and ELISA. It has been shown to detect SEM6D protein in a variety of tissues and cell types, including human, mouse, and rat. The antibody is supplied as a purified IgG fraction, which has been affinity-purified from rabbit serum using protein A chromatography. This ensures high purity and minimal background interference in downstream applications.

The SEM6D polyclonal antibody is a valuable tool for researchers studying the role of SEM6D protein in various biological processes, including cell adhesion, migration, and differentiation. It can also be used for the development of diagnostic assays for diseases associated with SEM6D protein dysregulation. With its high specificity and sensitivity, the SEM6D polyclonal antibody is a reliable and effective reagent for a wide range of applications in life sciences research and clinical diagnostics.