SCN1B Polyclonal Antibody

Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.

The SCN1B polyclonal antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of the SCN1B protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of the human SCN1B protein. The resulting polyclonal antibody exhibits high affinity and specificity towards the target protein, making it an ideal tool for a wide range of applications in research and diagnostics.

The SCN1B polyclonal antibody has been extensively validated for its performance in various immunoassays, including Western blotting, immunohistochemistry, and ELISA. It has been shown to detect endogenous levels of the SCN1B protein in human, mouse, and rat tissues with high sensitivity and specificity. The antibody is also suitable for use in immunoprecipitation and co-immunoprecipitation experiments, allowing for the isolation and identification of protein complexes containing the SCN1B protein.

The SCN1B polyclonal antibody is supplied as a purified IgG fraction, which has been affinity-purified from rabbit serum using protein A chromatography. The antibody is provided in a liquid format, ready to use for various applications. It is recommended to store the antibody at -20°C in aliquots to avoid repeated freeze-thaw cycles.

In summary, the SCN1B polyclonal antibody is a reliable and versatile tool for the detection and quantification of the SCN1B protein in various biological samples. Its high specificity and sensitivity make it an ideal reagent for research and diagnostic applications in neuroscience, cardiology, and other fields.