SARM1 Polyclonal Antibody

Was initially reported to contain ARM repeats (PubMed:11386760). Such repeats are however not predicted by any detection method.,Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.,Contains 1 TIR domain.,Contains 2 SAM (sterile alpha motif) domains.,subunit:Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function.,tissue specificity:Predominantly expressed in kidney and liver. Expressed at lower level in placenta.,

Introducing the SARM1 Polyclonal Antibody, a highly specific and sensitive tool for the detection of SARM1 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human SARM1 protein. The resulting polyclonal antibody has been extensively validated for its specificity and sensitivity in Western blotting, immunoprecipitation, and immunofluorescence assays.

The SARM1 protein is a key regulator of axonal degeneration and neuronal death, and its dysregulation has been implicated in various neurodegenerative diseases. The SARM1 Polyclonal Antibody enables researchers to investigate the expression, localization, and function of SARM1 protein in different cell types and tissues. It recognizes both the full-length and cleaved forms of SARM1 protein, and exhibits minimal cross-reactivity with other related proteins.

The SARM1 Polyclonal Antibody is supplied as a purified IgG fraction in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative. It is suitable for use in various applications, including Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry. It is recommended to use this antibody at a dilution of 1:1000 for Western blotting and 1:200 for immunofluorescence.

In summary, the SARM1 Polyclonal Antibody is a reliable and versatile tool for the detection and analysis of SARM1 protein in biological samples. Its high specificity and sensitivity make it an ideal choice for researchers studying the role of SARM1 in neurodegeneration and other cellular processes.