RUNX1(Phospho Ser249) Polyclonal Antibody

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

The RUNX1(PHOSPHO SER249) Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of the phosphorylated serine 249 residue of the RUNX1 protein. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and sensitivity for the target epitope.

The RUNX1 protein, also known as AML1, plays a crucial role in hematopoiesis and is involved in the regulation of various cellular processes. Phosphorylation of serine 249 has been shown to modulate the activity and function of RUNX1, making it an important post-translational modification to study.

This polyclonal antibody is rigorously validated for its specificity and performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other proteins, ensuring accurate and reliable results.

With its high sensitivity and specificity, the RUNX1(PHOSPHO SER249) Polyclonal Antibody is an indispensable tool for researchers studying the role of phosphorylation in the regulation of RUNX1 and its associated cellular processes. Its superior performance and reliability make it an ideal choice for both basic research and clinical applications.

Order your RUNX1(PHOSPHO SER249) Polyclonal Antibody today and unlock new insights into the intricate mechanisms of RUNX1 phosphorylation.