RIPK1 Polyclonal Antibody

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Promotes apoptosis and activation of NF-kappa-B. Required for TNFRSF1A mediated activation of NF-kappa-B.,PTM:Autophosphorylated on serine and threonine residues.,PTM:Proteolytically cleaved by caspase-8 during TNF-induced apoptosis. Cleavage abolishes NF-kappa-B activation and enhances pro-apototic signaling through the TRADD-FADD interaction.,Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,Contains 1 death domain.,Contains 1 protein kinase domain.,subunit:Binds to the death domain of TNFRSF6 and TRADD. Is recruited by TRADD to TNFRSF1A in a TNF-dependent process. Binds RIPK3, UBCE7IP1 isoform 3 (ZIN), EGFR, IKBKG, TRAF1, TRAF2 and TRAF3. Interacts with BNLF1. Interacts with SQSTM1 upon TNF-alpha stimulation. May interacts with MAVS/IPS1.,

The RIPK1 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Receptor-Interacting Protein Kinase 1 (RIPK1) in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human RIPK1 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The RIPK1 Polyclonal Antibody is suitable for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been validated for use in human, mouse, and rat samples and has been shown to exhibit high specificity and sensitivity in detecting RIPK1 protein expression.

This antibody is an essential tool for researchers studying the role of RIPK1 in various biological processes, including cell death, inflammation, and immune response. Its high specificity and sensitivity make it an ideal choice for detecting RIPK1 protein expression in complex biological samples.

In summary, the RIPK1 Polyclonal Antibody is a reliable and high-quality antibody that is essential for researchers studying the role of RIPK1 in various biological processes. Its high specificity and sensitivity make it an ideal choice for detecting RIPK1 protein expression in complex biological samples.