Rb (Acetyl-K873/K874) Polyclonal Antibody

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

The RB (ACETYL-K873/K874) polyclonal antibody is a highly specific and reliable tool for the detection and analysis of acetylated lysine residues at positions 873 and 874 of the RB protein. This antibody has been meticulously developed and rigorously validated to ensure optimal performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence.

The RB (ACETYL-K873/K874) polyclonal antibody exhibits exceptional sensitivity and specificity, enabling accurate and precise quantification of acetylated RB protein levels. Its superior affinity for acetylated lysine residues ensures minimal cross-reactivity with non-acetylated forms, thereby enhancing the accuracy of experimental results.

This antibody is manufactured using state-of-the-art techniques and undergoes stringent quality control measures to guarantee batch-to-batch consistency and reproducibility. It is supplied as a purified and concentrated solution, ensuring maximum potency and minimizing background noise.

The RB (ACETYL-K873/K874) polyclonal antibody is compatible with a wide range of sample types, including cell lysates, tissue extracts, and purified proteins. Its versatility allows for seamless integration into various research areas, such as cancer biology, epigenetics, and cell signaling.

In summary, the RB (ACETYL-K873/K874) polyclonal antibody is an indispensable tool for researchers seeking to investigate the acetylation status of RB protein at positions 873 and 874. Its exceptional specificity, sensitivity, and reliability make it an ideal choice for a multitude of applications, facilitating groundbreaking discoveries in the field of molecular biology.