Raf-1 Polyclonal Antibody

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

The Raf-1 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Raf-1 protein expression in various biological samples. This antibody is produced using advanced recombinant DNA technology, ensuring high purity and batch-to-batch consistency.

The Raf-1 Polyclonal Antibody exhibits exceptional affinity and specificity towards Raf-1, a key signaling molecule involved in the regulation of cell growth, differentiation, and survival. It recognizes both the active and inactive forms of Raf-1, enabling comprehensive analysis of its activation status.

This antibody has been extensively validated for various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It demonstrates excellent performance in detecting endogenous Raf-1 protein in cell lysates, tissue sections, and cultured cells.

The Raf-1 Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, ensuring cost-effectiveness and minimal wastage. The antibody is stable and can be stored at -20°C for long-term use.

With its superior sensitivity and specificity, the Raf-1 Polyclonal Antibody is an indispensable tool for researchers and scientists studying the intricate signaling pathways involving Raf-1. Its reliable performance and consistent results make it an ideal choice for a wide range of applications in both basic and clinical research.

Order your Raf-1 Polyclonal Antibody today and unlock new insights into the complex mechanisms governing cellular processes.