Raf-1(Phospho Ser338) Polyclonal Antibody

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

The RAF-1 Phospho-Ser338 Polyclonal Antibody, offered by BT Lab and available through Dana Biosciences, is a highly specific and sensitive tool for the detection of phosphorylated RAF-1 protein at serine 338. This antibody has been rigorously tested and validated for use in a variety of applications, including Western blotting, immunoprecipitation, and immunohistochemistry.

The RAF-1 protein is a key component of the MAPK/ERK signaling pathway, which plays a critical role in cell proliferation, differentiation, and survival. Phosphorylation of RAF-1 at serine 338 is a critical step in the activation of this pathway, and aberrant activation of this pathway has been implicated in a variety of diseases, including cancer.

The RAF-1 Phospho-Ser338 Polyclonal Antibody is produced using high-quality materials and state-of-the-art techniques, ensuring excellent specificity and sensitivity. This antibody has been extensively characterized and validated using a variety of cell lines and tissues, and has been shown to exhibit minimal cross-reactivity with non-phosphorylated RAF-1 protein.

In summary, the RAF-1 Phospho-Ser338 Polyclonal Antibody is a reliable and effective tool for the detection of phosphorylated RAF-1 protein at serine 338. Its high specificity and sensitivity make it an ideal choice for researchers studying the MAPK/ERK signaling pathway and its role in disease.