Rad17(Phospho Ser645) Polyclonal Antibody

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, h

The RAD17(PHOSPHO SER645) Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of RAD17 protein phosphorylated at serine 645. This antibody is produced using advanced polyclonal antibody production techniques, ensuring high affinity and specificity towards the target protein.

RAD17 is a crucial component of the DNA damage response pathway, playing a vital role in maintaining genomic stability. Phosphorylation of RAD17 at serine 645 is known to regulate its function and activation in response to DNA damage. Therefore, the RAD17(PHOSPHO SER645) Polyclonal Antibody serves as an invaluable tool for researchers studying DNA damage response, cell cycle regulation, and genomic stability.

This antibody has been extensively validated for various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate detection and quantification of phosphorylated RAD17 protein in various sample types.

The RAD17(PHOSPHO SER645) Polyclonal Antibody is supplied as a liquid formulation, ensuring ease of use and convenience. It is provided in a ready-to-use format, eliminating the need for time-consuming antibody preparation steps. The antibody is also available in different sizes to accommodate various experimental requirements.

With its exceptional performance and reliability, the RAD17(PHOSPHO SER645) Polyclonal Antibody is an indispensable tool for researchers investigating the intricate mechanisms of DNA damage response and genomic stability.