PXR Polyclonal Antibody

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.

The PXR Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of the Pregnane X Receptor (PXR) protein. This antibody is produced using a unique and advanced polyclonal antibody production process, ensuring high affinity and specificity towards the target protein.

The PXR Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated and proven to provide reliable and reproducible results across a wide range of sample types and species.

With its superior sensitivity, the PXR Polyclonal Antibody enables accurate and precise detection of even low-abundance PXR protein levels. This makes it an ideal choice for researchers and scientists working in the fields of drug metabolism, toxicology, and pharmacology, where the PXR protein plays a crucial role.

The PXR Polyclonal Antibody is manufactured under strict quality control standards, ensuring batch-to-batch consistency and reliability. It is supplied in a convenient and ready-to-use format, allowing for easy integration into laboratory workflows.

Choose the PXR Polyclonal Antibody for its exceptional performance, reliability, and specificity, and unlock new insights into the function and regulation of the Pregnane X Receptor protein.