PLIN3 Polyclonal Antibody

Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.

The PLIN3 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of PLIN3 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human PLIN3 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards PLIN3 protein, making it an ideal tool for various applications such as Western blotting, immunohistochemistry, and ELISA.

The PLIN3 Polyclonal Antibody is purified using a combination of protein A and peptide affinity chromatography, ensuring high purity and minimal cross-reactivity with other proteins. This antibody has been extensively validated for its specificity and sensitivity in various biological samples, including human, mouse, and rat tissues.

The PLIN3 protein, also known as perilipin-3 or TIP47, is a member of the perilipin family of proteins that play a crucial role in lipid metabolism and storage. PLIN3 is primarily localized to the cytoplasmic surface of lipid droplets in adipocytes and other cells, where it regulates lipid storage and mobilization. Dysregulation of PLIN3 expression and function has been implicated in various metabolic disorders, including obesity, diabetes, and cardiovascular diseases.

In summary, the PLIN3 Polyclonal Antibody is a reliable and high-quality reagent that can be used for the detection and quantification of PLIN3 protein in various biological samples. Its high specificity and sensitivity make it an ideal tool for researchers studying lipid metabolism and related disorders.