PLB(Phospho Ser16/T17) Polyclonal Antibody

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.

The PLB Phospho-Ser16/T17 Polyclonal Antibody, manufactured by BT Lab and distributed by Dana Biosciences, is a highly specific and sensitive tool for the detection of phospholamban (PLB) phosphorylation at serine residues 16 and 17. This antibody is produced using high-quality polyclonal antibodies that have been rigorously tested for specificity and sensitivity, ensuring reliable and reproducible results.

The PLB Phospho-Ser16/T17 Polyclonal Antibody is suitable for use in a variety of applications, including western blotting, immunoprecipitation, and immunohistochemistry. It has been validated for use in human, mouse, and rat samples, making it a versatile tool for researchers in a range of fields.

This antibody is supplied in a convenient 100 µg size, and is provided as a lyophilized powder for ease of storage and handling. It is recommended for use at a dilution of 1:1000 for western blotting, and 1:200 for immunohistochemistry.

Overall, the PLB Phospho-Ser16/T17 Polyclonal Antibody is a reliable and effective tool for the detection of PLB phosphorylation, and is an essential component of any researcher's toolkit.