Pim-1(Phospho Tyr309) Polyclonal Antibody

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).

The PIM-1(PHOSPHO TYR309) Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of PIM-1 protein phosphorylated at tyrosine 309 residue. This antibody is produced through a rigorous process of immunization using a synthetic peptide corresponding to the phosphorylated tyrosine 309 region of the PIM-1 protein.

With its exceptional sensitivity and specificity, this polyclonal antibody enables researchers to investigate the role of PIM-1 phosphorylation at tyrosine 309 in various cellular processes and signaling pathways. It is particularly useful in studies related to cancer research, as PIM-1 has been implicated in the development and progression of various malignancies.

The PIM-1(PHOSPHO TYR309) Polyclonal Antibody exhibits minimal cross-reactivity with non-phosphorylated PIM-1 protein, ensuring accurate and reliable results. It is suitable for various applications, including Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry.

This antibody is supplied as a liquid formulation, ready for immediate use. It has been validated for use in multiple species, including human, mouse, and rat, making it a versatile tool for researchers working with different model systems.

In summary, the PIM-1(PHOSPHO TYR309) Polyclonal Antibody is a high-quality reagent that offers exceptional sensitivity and specificity for the detection and analysis of phosphorylated PIM-1 protein at tyrosine 309 residue. Its reliability and versatility make it an invaluable tool for researchers in the field of cancer research and beyond.